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April 17, 2026 – Carfentanil, a weapons-grade chemical that authorities say is 10,000 times more potent than morphine and 100 times stronger than fentanyl, has seen a drastic resurgence across the U.S., killing hundreds of unsuspecting drug users. The rise coincides with a recent crackdown by the Chinese government on the sale of precursors used to make fentanyl. The rise coincides with a recent crackdown by the Chinese government on the sale of precursors used to make fentanyl. Those regulations are likely prompting traffickers in Mexico to use carfentanil to boost the potency of a weakened version of fentanyl, according to U.S. Drug Enforcement Administration intelligence bulletins reviewed by The Associated Press. The surge of a drug so deadly that less than a poppy seed-sized amount can kill a person comes as fentanyl seizures and overall drug overdose deaths continue a multiyear decline.
“You’re talking about not even a grain of salt that could be potentially lethal,” said Frank Tarentino, the DEA’s chief of operations for its northeast region, which stretches from Maine to Virginia. “This presents an extremely frightening proposition for substance abuse dependent people who seek opioids on the street today.”
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